Protonated cyclopropanes in α-aminoketone deamination
نویسندگان
چکیده
منابع مشابه
Oxidation cyclischer α-Aminoketone Oxidation of Cyclic α-Aminoketones
The 1,2,3,4-tetrahydro-isoquinolin-4-one 4 reacts as an α-amino ketone with periodate to give various products, the major compound being 1-hydroxy-1,2-dihydro-3,4-isoquinolinedione 12. Upon stepwise oxidation with Hg(II)-EDTA the 4-hydroxyisoquinolinium ion 14 is detected as an intermediate and its further oxidation with periodate gives rise to an almost identical product spectrum. Because 12 r...
متن کاملNeighbouring group processes in the deamination of protonated phenylalanine derivatives.
The gas-phase fragmentation of protonated phenylalanine and a series of its derivatives (tyrosine, 4-methylphenylalanine, 4-aminophenylalanine, 4-methoxyphenylalanine, 4-tert-butylphenylalanine, 4-fluorophenylalanine, 4-chlorophenylalanine, 4-bromophenylalanine, 4-iodophenylalanine, 4-cyanophenylalanine, 4-nitrophenylalanine, 3-fluorophenylalanine, and 3,4-dichlorophenylalanine) were examined u...
متن کاملDehydration versus deamination of N-terminal glutamine in collision-induced dissociation of protonated peptides.
Some of the most prominent "neutral losses" in peptide ion fragmentation are the loss of ammonia and water from N-terminal glutamine. These processes are studied by electrospray ionization mass spectrometry in singly- and doubly-protonated peptide ions undergoing collision-induced dissociation in a triple quadrupole and in an ion trap instrument. For this study, four sets of peptides were synth...
متن کاملNitrosative guanine deamination: ab initio study of deglycation of N-protonated 5-cyanoimino-4-oxomethylene-4,5-dihydroimidazoles.
5-Cyanoimino-4-oxomethylene-4,5-dihydroimidazoles (1) (R at N1) have been discussed as possible intermediates in nitrosative guanine deamination, which are formed by dediazoniation and deprotonation of guaninediazonium ion. The parent system 1 (R = H) and its N1 derivatives 2 (R = Me) and 3 (R = MOM) are considered here. Protonation of 1-3, respectively, may occur either at the cyano-N to form ...
متن کاملAminoketone Rearrangements . 11 . The Rearrangement of Phenyl a - Aminoketonesl
Phenyl a-aminoketones have been shown to undergo carbon skeleton rearrangement to unconjugated aminoketones when heated a t 200-240". The probable intermediate is an unconjugated hydroxyimine formed by base removal of an amine hydrogen and migration of an alkyl group. The hydroxyimine can subsequently rearrange by base removal of a hydroxyl proton and migration of the phenyl grouping. An amine ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1981
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v81-305